Citation
Ramli, Zarina
(2024)
Radiomics analysis and supervised machine learning model for classification of cervical cancer images using diffusion weighted imaging-MRI.
Doctoral thesis, Universiti Putra Malaysia.
Abstract
Cervical cancer is the third most prevalent cause of mortality among women in
Malaysia. Early detection, especially in high-risk populations, can reduce mortality
rates and enable timely treatment. This study investigates the efficacy of staging
classification using diffusion-weighted imaging magnetic resonance imaging (DWIMRI)
through radiomic analysis and machine learning. Data were retrospectively
analyzed from the picture archiving and communication system (PACS) at Institut
Kanser Negara (IKN) in Putrajaya, Malaysia. The first objective involved 30 patients
to evaluate the repeatability and reproducibility of manual and semi-automated
segmentation methods on DWI-MRI images. Intra-class correlation coefficient (ICC)
analyses were performed on 662 radiomic features encompassing texture, shape, and
first-order statistics. The semi-automated active contour model (ACM) algorithm
(average ICC = 0.952 ± 0.009, p > 0.05) was found to be more robust and reproducible
than fully manual segmentation (average ICC = 0.897 ± 0.011, p > 0.05). The second
objective assessed the stability of radiomic features using contrast-limited adaptive
histogram equalization (CLAHE) for image enhancement of 80 DWI-MRI images,
enhanced images exhibited improved stability in radiomic features (ICC = 0.990 ±
0.005, p < 0.05), outperforming both semi-automated (ICC = 0.864 ± 0.033, p < 0.05)
and manual methods (ICC = 0.554 ± 0.185, p > 0.05). The third objective focused on
classifying cervical cancer stages using DWI-MRI radiomic features. A support vector
machine (SVM) classifier yielded excellent performance metrics, accuracy of 0.77,
and precision of 0.63, with an area under the curve (AUC) of 96%. Additionally, the
SVM algorithm was evaluated based on its performance across different DWI bvalues,
aiming to optimize scanning time. In conclusion, SVM-based models can
develop accurate and reproducible software for classifying cervical cancer stages,
significantly enhancing the role of radiology by enabling more quantitative MRI
interpretations. This study underscores the potential of radiomic analysis to improve
the accuracy of medical reports, reduce dependency on contrast agents, and enhance
early detection of cervical cancer.
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Additional Metadata
Item Type: |
Thesis
(Doctoral)
|
Subject: |
Cervix uteri - Cancer - Diagnosis |
Subject: |
Magnetic resonance imaging |
Subject: |
Radiomics |
Call Number: |
FS 2024 18 |
Chairman Supervisor: |
Associate Professor Muhammad Khalis bin Abdul Karim, PhD |
Divisions: |
Faculty of Science |
Keywords: |
Cervical cancer, DWI-MRI, Radiomic analysis, Supervised machine
learning. |
Depositing User: |
Ms. Rohana Alias
|
Date Deposited: |
02 Sep 2025 07:17 |
Last Modified: |
02 Sep 2025 07:17 |
URI: |
http://psasir.upm.edu.my/id/eprint/119334 |
Statistic Details: |
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