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Cytotoxicity studies of curcumin loaded-cockle shell-derived calcium carbonate nanoparticles


Citation

Muhammad, Mailafiya Maryam and Mohd Moklas, Mohamad Aris and Abubakar, Kabeer and Danmaigoro, Abubakar and Chiroma, Samaila Musa and Abdul Rahim, Ezamin and Abu Bakar Zakaria, Md Zuki (2021) Cytotoxicity studies of curcumin loaded-cockle shell-derived calcium carbonate nanoparticles. Nanoscience and Nanotechnology - Asia, 11 (1). 35 - 41. ISSN 2210-6812; ESSN: 2210-6820

Abstract

Background: Cockle shell-derived calcium carbonate nanoparticles (CSCaCO3NP) are natural biogenic inorganic material that is used in drug delivery mainly as a bone-remodeling agent as well as a delivery agent for various therapeutics against bone diseases. Curcumin possesses a wide safety margin and yet puzzled with the problem of poor bioavailability due to insolubility. Propounding in vitro and in vivo studies on toxicity assessments of newly synthesized nanoparticles are ongoing to overcome some crucial challenges regarding their safety administration. Nanotoxicology has paved ways for concise test protocols to monitor sequential events with regards to possible toxicity of newly synthesized nanomaterials. The development of nanoparticle with no or less toxic effect has gained tremendous attention. Objective: This study aimed at evaluating the in vitro cytotoxic effect of curcumin-loaded cockle shell-derived calcium carbonate nanoparticles (Cur-CSCaCO3NP) and assessing its biocompatibility on normal cells using standard techniques of WST’s assay. Methods: Standard techniques of WST’s assay was used for the evaluation of the biocompatibility and cytotoxicity. Results: The result showed that CSCaCO3NP and Cur-CSCaCO3NP possess minimal toxicity and high biocompatibility on normal cells even at a higher dose of 500 μg/ml and 40 μg/ml, respectively. Conclusion: CSCaCO3NP can be termed an excellent non-toxic nanocarrier for curcumin delivery. Hence, curcumin loaded cockle shell derived calcium carbonate nanoparticles (Cur-CSCaCO3NP) could further be assessed for various in vivo and in vitro therapeutic applications against various bone- related ailments.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Faculty of Veterinary Medicine
DOI Number: https://doi.org/10.2174/2210681209666191128155819
Publisher: Bentham Science Publishers
Keywords: Cockleshell; Canoparticles; Curcumin; Cytotoxicity; Calcium carbonate; Polyphenolic phytochemical
Depositing User: Ms. Nuraida Ibrahim
Date Deposited: 11 Jan 2023 08:23
Last Modified: 11 Jan 2023 08:23
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.2174/2210681209666191128155819
URI: http://psasir.upm.edu.my/id/eprint/96594
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