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Bone single-photon emission computed tomography/computed tomography in cancer care in the past decade: a systematic review and meta-analysis as well as recommendations for further work


Citation

Mohd Rohani, Mohd Fazrin and Zanial, Ahmad Zaid and Suppiah, Subapriya and Khor, Phay Phay and Mohamed Aslum Khan, Farahnaz and Mohamad Najib, Fatin Hayyani and Mohd Noor, Noramaliza and Arumugam, Manohar and Amir Hassan, Siti Zarina and Vinjamuri, Sobhan (2021) Bone single-photon emission computed tomography/computed tomography in cancer care in the past decade: a systematic review and meta-analysis as well as recommendations for further work. Nuclear Medicine Communications, 42 (1). pp. 9-20. ISSN 0143-3636; ESSN: 1473-5628

Abstract

Skeletal whole-body scintigraphy (WBS), although widely used as a sensitive tool for detecting metastatic bone disease in oncology cases, has relatively low specificity. Indeterminate bone lesions (IBLs) detected by WBS cause a diagnostic dilemma, which hampers further management plans. In the advent of hybrid imaging, single-photon emission computed tomography/computed tomography (SPECT/CT) has been gaining popularity as a tool to improve the characterisation of IBLs detected by WBS. As yet, there has not been a systematic review to objectively evaluate the diagnostic capabilities of SPECT/CT in this area. We conducted a systematic review of relevant electronic databases up to 30 August 2020. The outcomes of interest were the reporting of SPECT/CT to identify benign and malignant IBLs and the calculation of the sensitivity and specificity of the index test, based on histopathological examination or clinical and imaging follow-up as the reference standard. After the risk of bias and eligibility assessment, 12 articles were identified and synthesised in the meta-analysis. The pooled sensitivity and specificity of SPECT/CT for diagnosing IBLs are 93.0% [95% confidence interval (CI) 0.91-0.95] and 96.0% (95% CI 0.94-0.97), respectively. There was heterogeneity of the articles due to variable imaging protocols, duration of follow-up and scoring methods for interpreting the SPECT/CT results. The heterogeneity poses a challenge for accurate interpretation of the true diagnostic capability of SPECT/CT. In conclusion, targeted SPECT/CT improves the specificity of diagnosing bone metastases, but efforts need to be made to standardise the thresholds for SPECT/CT, methodology, as well as harmonising the reporting and interpretation criteria. We also make some recommendations for future works.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1097/MNM.0000000000001306
Publisher: Lippincott, Williams & Wilkins
Keywords: Bone metastases; Bone scintigraphy; Indeterminate bone lesion; Oncology; Planar bone scan; Single-photon emission computed tomography; Computed tomography; Whole-body scintigraphy
Depositing User: Ms. Nuraida Ibrahim
Date Deposited: 31 Jan 2023 02:54
Last Modified: 31 Jan 2023 02:54
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1097/MNM.0000000000001306
URI: http://psasir.upm.edu.my/id/eprint/96258
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