UPM Institutional Repository

A review of the neuroprotective effects of andrographolide in Alzheimer's disease


Citation

Abedi, Zahra and Hassan, Zurina and Basri, Hamidon and Inche Mat, Liyana Najwa and Khaza’ai, Huzwah and Mohamad, Nur Afiqah (2021) A review of the neuroprotective effects of andrographolide in Alzheimer's disease. Advances in Traditional Medicine, 21. pp. 253-266. ISSN 2662-4060

Abstract

Alzheimer’s disease, characterized by amyloid beta peptides and neurofibrillary tangles, is the most prevalent cause of dementia. Nowadays, some novel medicines being developed have displayed more illustrious therapeutic efficacies in Alzheimer’s disease. Recent studies have found andrographolide exhibiting therapeutic efficacy in a variety of Alzheimer’s disease models. Andrographolide is a traditional herbal medicine compound extracted from Andrographis paniculata. Evidence has shown that andrographolide reduces amyloid beta aggregation and suppresses neuroinflammatory response and synaptic dysfunction by reversing the microglia-mediated production of pro-inflammatory cytokines as well as Alzheimer’s disease-associated reduction in synaptic proteins. In the present review, the pharmacological effects of andrographolide are summarized and its mechanism of action against Alzheimer’s disease is discussed to discover the possibilities of andrographolide for Alzheimer’s disease prevention and therapy.


Download File

Full text not available from this repository.

Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1007/s13596-021-00573-8
Publisher: Springer
Keywords: Alzheimer; Dementia; Therapeutic; Herbal medicine; Neuroinflammatory
Depositing User: Ms. Nuraida Ibrahim
Date Deposited: 13 Mar 2023 04:00
Last Modified: 13 Mar 2023 04:00
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1007/s13596-021-00573-8
URI: http://psasir.upm.edu.my/id/eprint/96019
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item