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The IntelliCage system: a review of its utility as a novel behavioral platform for a rodent model of substance use disorder


Citation

Nurul Iman, Ismail and Mohd Yusof, Nurul Aiman and Talib, Ummi Nasrah and Ahmad, Nur Aimi Zawami and Norazit, Anwar and Kumar, Jaya and Mehat, Muhammad Zulfadli and Jayabalan, Nanthini and Muthuraju, Sangu and Stefaniuk, Marzena and Kaczmarek, Leszek and Muzaimi, Mustapha (2021) The IntelliCage system: a review of its utility as a novel behavioral platform for a rodent model of substance use disorder. Frontiers in Behavioral Neuroscience, 15 (-). pp. 1-13. ISSN ESSN:1662-5153

Abstract

The use of animal models for substance use disorder (SUD) has made an important contribution in the investigation of the behavioral and molecular mechanisms underlying substance abuse and addiction. Here, we review a novel and comprehensive behavioral platform to characterize addiction-like traits in rodents using a fully automated learning system, the IntelliCage. This system simultaneously captures the basic behavioral navigation, reward preference, and aversion, as well as the multi-dimensional complex behaviors and cognitive functions of group-housed rodents. It can reliably capture and track locomotor and cognitive pattern alterations associated with the development of substance addiction. Thus, the IntelliCage learning system offers a potentially efficient, flexible, and sensitive tool for the high-throughput screening of the rodent SUD model.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.3389/fnbeh.2021.683780
Publisher: Frontiers Research Foundation
Keywords: IntelliCage system; Addiction; Behavior; Home cage; Rodent model; Substance use disorder (SUD)
Depositing User: Ms. Che Wa Zakaria
Date Deposited: 28 Dec 2022 08:37
Last Modified: 28 Dec 2022 08:37
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3389/fnbeh.2021.683780
URI: http://psasir.upm.edu.my/id/eprint/95505
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