Citation
Hassan, Hishar and Othman, Muhammad Faiz and Abdul Razak, Hairil Rashmizal
(2021)
Optimal 18F-fluorination conditions for the high radiochemical yield of [18F]AlF-NOTA-NHS complexes.
Radiochimica Acta, 109 (7).
567 - 574.
ISSN 0033-8230; ESSN: 2193-3405
Abstract
18F-fluorination using aluminum-fluoride ([18F]AlF) chelate technique has been reported to give a low-to-moderate radiochemical yield, between 5 and 20%. Therefore, the work described here outlines the optimum 18F-fluorination condition for the formation of [18F]AlF2+ and [18F]AlF-NOTA-NHS complex with the radiochemical yield (RCY) and purity (RCP) of more than 90% as a prerequisite step before proceeding with the radiopharmaceutical preparation using the [18F]AlF-bifunctional chelator technique. As well as being simple, the suggested method is practical and relevant for beginners interested in 18F-fluorination with [18F]AlF-chelate complex technique or also for a researcher who aims to proceed on an extensive scale.
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Medicine and Health Science |
| DOI Number: | https://doi.org/10.1515/ract-2021-1024 |
| Publisher: | De Gruyter |
| Keywords: | Aluminum-fluoride; Bifunctional chelating agent; Fluorine-18; NOTA chelator; Radiochemistry; Radiofluorination |
| Depositing User: | Ms. Nur Faseha Mohd Kadim |
| Date Deposited: | 04 Apr 2023 01:57 |
| Last Modified: | 04 Apr 2023 01:57 |
| Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1515/ract-2021-1024 |
| URI: | http://psasir.upm.edu.my/id/eprint/94441 |
| Statistic Details: | View Download Statistic |
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