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NeuroAid II (MLC901) and polypharmacy in stroke and the risk of hepatotoxicity: a case report


Citation

Abdul Rashid, Anna Misya’il and Md Noh, Mohamad Syafeeq Faeez and Yusof Khan, Abdul Hanif Khan and Wei, Chao Loh and Baharin, Janudin and Ibrahim, Azliza and Inche Mat, Liyana Najwa and Wan Sulaiman, Wan Aliaa and Fan, Kee Hoo and Hanapiah, Fazah Akhtar and Basri, Hamidon (2021) NeuroAid II (MLC901) and polypharmacy in stroke and the risk of hepatotoxicity: a case report. The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 57. art. no. 151. pp. 1-6. ISSN 1687-8329

Abstract

Background: NeuroAid II (MLC901) is a promising therapy for stroke patients who present outside of therapeutic window for reperfusion therapy. Studies have proven its efcacy in ischemic stroke; however, data of drug safety and combination with other medications especially anticoagulants are heterogenous. We report a possible case of hepatotoxicity induced by NeuroAid II in combination with anticoagulants. Case presentation: We report an elderly patient who developed symptoms of cardioembolic stroke presented outside of time window for reperfusion therapy. He was started on a regiment of statins, anticoagulation, beta blockers and NeuroAid II. One month later he presented with deranged liver enzymes. Cessation of NeuroAid II resulted in rapid improvement of transaminitis within days. Conclusions: We wish to highlight the potential harmful efect of administering NeuroAid II with an anticoagulant and the importance of routine follow-up and blood monitoring in the elderly patients with stroke.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.1186/s41983-021-00397-y
Publisher: SpringerOpen
Keywords: Stroke; Chinese traditional medication; Hepatotoxicity; NeuroAid II; Elderly
Depositing User: Ms. Nur Faseha Mohd Kadim
Date Deposited: 07 Apr 2023 03:45
Last Modified: 07 Apr 2023 03:45
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1186/s41983-021-00397-y
URI: http://psasir.upm.edu.my/id/eprint/94347
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