Citation
Abstract
Background: Breast cancer is one of the most common types of cancer and heterogeneous disease. Somatostatin receptors (SSTRs) are expressed in normal and tumour tissues including breast cancer cells. Objective: The aim of this study to evaluate the expression of SSTRs subtypes 1 – 5 in MCF7 and MDA-MB231 human breast cancer cell lines and compare the levels between two cells. Methods: The detection of mRNA expression levels of SSTRs in MCF7 and MDA-MB231 was performed using quantitativepolymerase chain reaction (qPCR). Results: SSTR1, 2, 3 and 4 mRNA levels were significantly higher in MDA-MB-231 about MCF-7. The expression of SSTR 4 mRNA was highest in MDA-MB231 and MCF-7 cell lines, however, SSTR3 mRNA was least expressed in both cell lines. Conclusion: SSTRs subtypes (1 – 5) were expressed in both MDA-MB231 and MCF7 cells. However, the levels of expression differ between both cell lines.
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Official URL or Download Paper: https://ijcrr.com/abstract.php?article_id=3497
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Additional Metadata
Item Type: | Article |
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Divisions: | Faculty of Veterinary Medicine |
DOI Number: | https://doi.org/10.31782/IJCRR.2021.13601 |
Publisher: | Radiance Bahu - Uddeshiya Sanstha |
Keywords: | Breast cancer; Cell lines; Somatostatin receptors; mRNA expression |
Depositing User: | Ms. Nur Faseha Mohd Kadim |
Date Deposited: | 08 May 2023 04:41 |
Last Modified: | 08 May 2023 04:41 |
Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.31782/IJCRR.2021.13601 |
URI: | http://psasir.upm.edu.my/id/eprint/94283 |
Statistic Details: | View Download Statistic |
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