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mRNA expression of Somatostatin receptors 1-5 in MCF7 and MDA-MB231 breast cancer cells


Citation

Mahmoud, Alkhansa and Mancuso, María Teresa and Tanno, Barbara and Abu Bakar, Md Zuki and Hamzah, Hazilawati and Mohd Noor, Mohd Hezmee (2021) mRNA expression of Somatostatin receptors 1-5 in MCF7 and MDA-MB231 breast cancer cells. International Journal of Current Research and Review, 13 (6). pp. 9-13. ISSN 2231-2196; ESSN: 0975-5241

Abstract

Background: Breast cancer is one of the most common types of cancer and heterogeneous disease. Somatostatin receptors (SSTRs) are expressed in normal and tumour tissues including breast cancer cells. Objective: The aim of this study to evaluate the expression of SSTRs subtypes 1 – 5 in MCF7 and MDA-MB231 human breast cancer cell lines and compare the levels between two cells. Methods: The detection of mRNA expression levels of SSTRs in MCF7 and MDA-MB231 was performed using quantitativepolymerase chain reaction (qPCR). Results: SSTR1, 2, 3 and 4 mRNA levels were significantly higher in MDA-MB-231 about MCF-7. The expression of SSTR 4 mRNA was highest in MDA-MB231 and MCF-7 cell lines, however, SSTR3 mRNA was least expressed in both cell lines. Conclusion: SSTRs subtypes (1 – 5) were expressed in both MDA-MB231 and MCF7 cells. However, the levels of expression differ between both cell lines.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Veterinary Medicine
DOI Number: https://doi.org/10.31782/IJCRR.2021.13601
Publisher: Radiance Bahu - Uddeshiya Sanstha
Keywords: Breast cancer; Cell lines; Somatostatin receptors; mRNA expression
Depositing User: Ms. Nur Faseha Mohd Kadim
Date Deposited: 08 May 2023 04:41
Last Modified: 08 May 2023 04:41
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.31782/IJCRR.2021.13601
URI: http://psasir.upm.edu.my/id/eprint/94283
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