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Microglia-induced neurotoxicity: a review of in vitro co-culture models


Ahmad Puzi, Nur Nabilah and Vidyadaran, Sharmili (2020) Microglia-induced neurotoxicity: a review of in vitro co-culture models. Malaysian Journal of Medicine and Health Sciences, 16 (suppl. 9). pp. 97-113. ISSN 1675-8544; ESSN: 2636-9346


Microglia-induced neurotoxicity occurs when inflammation mediated by microglia causes loss of neuronal structures or functions in the central nervous system implicated in stroke, spinal cord injury, sepsis, neurodegenerative diseases and even psychiatric illnesses. Various co-culture in vitro microglia-induced neurotoxicity (MINT) models have been established to enable an in-depth study of this process and yet there is a dearth of information regarding usages, advantages and limitations of each of the components of this model. In this review, we examined 56 MINTs for the cells, stimuli, parameters, methods of neurotoxicity measurement and formats of co-culture used in their construction. We aim to provide foundational information, overall guideline and framework for the novice researcher to develop his/her own model and for the advancement of improved, novel and more representative MINT models.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
Keywords: Microglia; Neurotoxicity; Coculture models; Neurites; Cell survival
Depositing User: Mohamad Jefri Mohamed Fauzi
Date Deposited: 09 Sep 2021 11:23
Last Modified: 09 Sep 2021 11:23
URI: http://psasir.upm.edu.my/id/eprint/90196
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