Citation
Abstract
The effect of saffron extract (Crocus sativus L.) and its primary compound crocin was studied on an induced obesity rat model. Our study is aimed at investigating and comparing the metabolite changes in obese and obese treated with saffron extract and crocin and at improving the understanding of the therapeutic effect of saffron extract and crocin. Two different doses of saffron extracts and crocin (40 and 80 mg/kg) were incorporated in a high-fat diet (HFD) and were given for eight weeks to the obese rats. The changes in metabolite profiles of the serum were determined using proton nuclear magnetic resonance (1H-NMR). Pattern recognition by multivariate data analysis (MVDA) showed that saffron extract and crocin at 80 mg/kg was the best dosage compared to 40 mg/kg. It also showed that both treatments work in different pathways, especially concerning glucose, lipid, and creatinine metabolism. In conclusion, although the pure compound, crocin, is superior to the saffron crude extract, this finding suggested that the saffron extract can be considered as an alternative aside from crocin in treating obesity.
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Official URL or Download Paper: https://www.hindawi.com/journals/bmri/2020/1247946...
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Additional Metadata
Item Type: | Article |
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Divisions: | Faculty of Food Science and Technology Faculty of Medicine and Health Science Halal Products Research Institute Institute of Bioscience |
DOI Number: | https://doi.org/10.1155/2020/1247946 |
Publisher: | Hindawi |
Keywords: | Obesity; Noncommunicable diseases; Saffron; World Health Organization (WHO) |
Depositing User: | Ms. Nuraida Ibrahim |
Date Deposited: | 03 Nov 2021 07:02 |
Last Modified: | 03 Nov 2021 07:02 |
Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1155/2020/1247946 |
URI: | http://psasir.upm.edu.my/id/eprint/88633 |
Statistic Details: | View Download Statistic |
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