Citation
Abstract
Plants and plant-based products have been used for a long time for medicinal purposes. This study aimed to determine the antioxidant and anti-α-glucosidase activities of eight selected underutilized plants in Malaysia: Leucaena leucocephala, Muntingia calabura, Spondias dulcis, Annona squamosa, Ardisia elliptica, Cynometra cauliflora, Ficus auriculata, and Averrhoa bilimbi. This study showed that the 70% ethanolic extract of all plants exhibited total phenolic content (TPC) ranging from 51 to 344 mg gallic acid equivalent (GAE)/g dry weight. A. elliptica showed strong 2,2-diphenyl-1-picrylhydrazyl (DPPH) and nitric oxide (NO) scavenging activities, with half maximal inhibitory concentration (IC50) values of 2.17 and 49.43 μg/mL, respectively. Most of the tested plant extracts showed higher inhibition of α-glucosidase enzyme activity than the standard, quercetin, particularly A. elliptica, F. auriculata, and M. calabura extracts with IC50 values of 0.29, 0.36, and 0.51 μg/mL, respectively. A total of 62 metabolites including flavonoids, triterpenoids, benzoquinones, and fatty acids were tentatively identified in the most active plant, i.e., A. elliptica leaf extract, by using ultra-high-performance liquid chromatography (UHPLC)–electrospray ionization (ESI) Orbitrap MS. This study suggests a potential natural source of antioxidant and α-glucosidase inhibitors from A. elliptica.
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Official URL or Download Paper: https://www.mdpi.com/1420-3049/25/13/3067
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Additional Metadata
Item Type: | Article |
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Divisions: | Faculty of Food Science and Technology Institute of Bioscience |
DOI Number: | https://doi.org/10.3390/molecules25133067 |
Publisher: | Multidisciplinary Digital Publishing Institute |
Keywords: | Underutilized plants; Antioxidant; Free radical scavenging; Anti-α-glucosidase; Phytochemical characterization |
Depositing User: | Ms. Nuraida Ibrahim |
Date Deposited: | 24 May 2022 04:52 |
Last Modified: | 24 May 2022 04:52 |
Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/molecules25133067 |
URI: | http://psasir.upm.edu.my/id/eprint/88037 |
Statistic Details: | View Download Statistic |
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