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Ameliorative effect of curcumin on lead-induced hematological and hepatorenal toxicity in a rat model


Citation

Abubakar, Kabeer and Mailafiya, Maryam M. and Chiroma, Samaila Musa and Danmaigoro, Abubakar and Zyoud, Tawfiq Y. T. and Abdul Rahim, Ezamin and Abu Bakar @ Zakaria, Md Zuki (2020) Ameliorative effect of curcumin on lead-induced hematological and hepatorenal toxicity in a rat model. Journal of Biochemical and Molecular Toxicology, 34 (6). art. no. 22483. pp. 1-15. ISSN 1095-6670; ESSN: 1099-0461

Abstract

Introduction: Lead (Pb) is a ubiquitous toxic heavy metal that inflicts numerous clinical consequences on humans. Curcumin is the principal component of turmeric, which is reported to have antioxidative properties. This study aimed at evaluating the ameliorative effects of curcumin on Pb-induced hepatorenal toxicity in a rat model. Methods: Thirty-six male Sprague-Dawley rats were randomly assigned into five groups with 12 rats in the control (normal saline) and six rats each for the lead-treated group (LTG) (50 mg/kg lead acetate [Pb acetate] for 4 weeks), recovery group (50 mg/kg Pb acetate for 4 weeks and left with no treatment for another 4 weeks), treatment group 1 (Cur100) (50 mg/kg Pb acetate for 4 weeks, followed by 100 mg/kg curcumin for 4 weeks), and treatment group 2 (Cur200) (50 mg/kg Pb acetate for 4 weeks, followed by 200 mg/kg curcumin for 4 weeks). All the experimental groups received oral treatments via orogastric-tube on alternate days. Pb concentration in the liver and kidney of the rats were evaluated using inductive-coupled plasma mass spectrometry techniques. Results: Pb-administered rats revealed significant alteration in oxidative status and increased Pb concentration in their liver and kidney with obvious reduction of hemogram and increased in leukogram as well as aberration in histological architecture of the liver and kidney. However, treatment with curcumin reduces the tissue Pb concentrations and ameliorates the above mention alterations. Conclusions: The results in this study suggested that curcumin attenuates Pb-induced hepatorenal toxicity via chelating activity and inhibition of oxidative stress.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Faculty of Veterinary Medicine
DOI Number: https://doi.org/10.1002/jbt.22483
Publisher: John Wiley and Sons
Keywords: ICP-MS; Curcumin; Hepatorenal toxicity; Lead toxicity; Oxidative stress
Depositing User: Ms. Nuraida Ibrahim
Date Deposited: 15 Jun 2022 07:03
Last Modified: 15 Jun 2022 07:03
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1002/jbt.22483
URI: http://psasir.upm.edu.my/id/eprint/87803
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