Potential miRNAs for miRNA-based therapeutics in breast cancer

Citation

Wong, Jun Sheng and Cheah, Yoke Kqueen (2020) Potential miRNAs for miRNA-based therapeutics in breast cancer. Non-coding RNA, 6 (3). art. no. 29. pp. 1-39. ISSN 2311-553X

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that can post-transcriptionally regulate the genes involved in critical cellular processes. The aberrant expressions of oncogenic or tumor suppressor miRNAs have been associated with cancer progression and malignancies. This resulted in the dysregulation of signaling pathways involved in cell proliferation, apoptosis and survival, metastasis, cancer recurrence and chemoresistance. In this review, we will first (i) provide an overview of the miRNA biogenesis pathways, and in vitro and in vivo models for research, (ii) summarize the most recent findings on the roles of microRNAs (miRNAs) that could potentially be used for miRNA-based therapy in the treatment of breast cancer and (iii) discuss the various therapeutic applications.

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Official URL or Download Paper: https://www.mdpi.com/2311-553X/6/3/29

Additional Metadata

Item Type:	Article
Divisions:	Faculty of Medicine and Health Science
DOI Number:	https://doi.org/10.3390/ncrna6030029
Publisher:	Multidisciplinary Digital Publishing Institute
Keywords:	Breast cancer; MicroRNAs; Cell line; miRNA-based therapeutics
Depositing User:	Mohamad Jefri Mohamed Fauzi
Date Deposited:	20 Jan 2022 02:41
Last Modified:	20 Jan 2022 02:41
Altmetrics:	http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3390/ncrna6030029
URI:	http://psasir.upm.edu.my/id/eprint/87221
Statistic Details:	View Download Statistic

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