Possible epigenetic role of vitexin in regulating neuroinflammation in Alzheimer’s disease

Citation

Yahaya, Muhamad Afiq Faisal and Zolkiffly, Siti Zaidathul Iman and Mohd Moklas, Mohamad Aris and Abdul Hamid, Hafizah and Zainol, Murizal and Mehat, Muhammad Zulfadli (2020) Possible epigenetic role of vitexin in regulating neuroinflammation in Alzheimer’s disease. Journal of Immunology Research, 2020. art. no. 9469210. pp. 1-7. ISSN 2314-8861; ESSN: 2314-7156

Abstract

Alzheimer’s disease (AD) has been clinically characterized by a progressive degeneration of neurons which resulted in a gradual and irreversible cognitive impairment. The accumulation of Aβ and τ proteins in the brain contribute to the severity of the disease. Recently, vitexin compound has been the talk amongst researchers due to its pharmacological properties as anti-inflammation and anti-AD. However, the epigenetic mechanism of the compound in regulating the neuroinflammation activity is yet to be fully elucidated. Hence, this review discusses the potential of vitexin compound to have the pharmacoepigenetic property in regulating the neuroinflammation activity in relation to AD. It is with hope that the review would unveil the potential of vitexin as the candidate in treating AD.

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Additional Metadata

Item Type:	Article
Divisions:	Faculty of Medicine and Health Science
DOI Number:	https://doi.org/10.1155/2020/9469210
Publisher:	Hindawi
Keywords:	Alzheimer’s disease (AD); Neuroinflammation; Vitexin; Epigenetic regulator
Depositing User:	Mohamad Jefri Mohamed Fauzi
Date Deposited:	19 Jan 2022 02:47
Last Modified:	19 Jan 2022 02:47
Altmetrics:	http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1155/2020/9469210
URI:	http://psasir.upm.edu.my/id/eprint/87214
Statistic Details:	View Download Statistic

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