Citation
Habibi, Azizollah and Khosravi, Sahar and Seyyed, Mohammad Shahcheragh and Abdul Rahman, Mohd Basyaruddin
(2020)
One-pot green synthesis of some novel n-substituted 5-amino-1,3,4-thiadiazole derivatives.
Letters in Organic Chemistry, 17 (7).
517 - 522.
ISSN 1570-1786; ESSN: 1875-6255
Abstract
In the current study, a green, one-pot, three-component reaction was performed to prepare novel N-substituted 5-amino-1,3,4-thiadiazole derivatives. The thiadiazoles were obtained from the reaction of a ketene S,S-acetal of Meldrum’s acid or barbituric acid (as key intermediates), hydrazine, and isothiocyanate. The key advantages of this manner include environmentally safe reactions, high yield, appropriate reaction time, simple reaction conditions, and use of a green reaction solvent. The structure of thiadiazoles was determined based on the spectroscopic data.
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Science |
| DOI Number: | https://doi.org/10.2174/1570178616666190926105533 |
| Publisher: | Bentham Science |
| Keywords: | 5-amino-1; 3; 4-thiadiazole; Thiosemicarbazide; Ketene S; S-acetal; Meldrum’s acid; Barbituric acid; Deep Eutectic Solvents |
| Depositing User: | Mohamad Jefri Mohamed Fauzi |
| Date Deposited: | 10 Jan 2022 08:12 |
| Last Modified: | 10 Jan 2022 08:12 |
| Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.2174/1570178616666190926105533 |
| URI: | http://psasir.upm.edu.my/id/eprint/86982 |
| Statistic Details: | View Download Statistic |
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