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Therapeutic targets on toxoplasma gondii parasite in combatting toxoplasmosis


Citation

Abdullahi, Sharif Alhassan and Unyah, Ngah Zasmy and Nordin, Noshariza and Basir, Rusliza and Mohammed Nasir, Wana and Ahmad Alapid, Ashraf and Hassan, Yahaya and Mustapha, Tijjani and Abd Majid, Roslaini (2019) Therapeutic targets on toxoplasma gondii parasite in combatting toxoplasmosis. Annual Research & Review in Biology, 32 (2). pp. 1-15. ISSN 2347-565X

Abstract

The status of toxoplasmosis management is challenged by drug intolerance, compromised efficacy and potential development of drug resistance. However, currently, there are very limited targets on T. gondii that serve as the site of action of current medications. This review aimed to explore more potential targets that are essential to parasite survival and are absent in humans. Many unexplored targets on T. gondii exist and their specificities to the parasite make them ideal drug targets. The present review had searched relevant English databases such as PubMed, Scopus, Google scholar and Science Direct, for relevant literature on the therapeutic target of T. gondii. Many of the enzyme systems in several pathways are essentially palatable as drug targets. Establishing compounds that can target these enzymes on T. gondii will greatly be beneficial in treating acute and chronic toxoplasmosis in humans.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
DOI Number: https://doi.org/10.9734/arrb/2019/v32i230081
Publisher: Sciencedomain International
Keywords: Toxoplasmosis; T. gondii; Essential; Drug; Targets; Enzymes
Depositing User: Mr. Sazali Mohamad
Date Deposited: 09 Jun 2021 02:28
Last Modified: 09 Jun 2021 02:28
Altmetrics: http://www.altmetrics.com/details.php?domain=pasir.upm.edu.my&doi=10.9734/arrb/2019/v32i230081
URI: http://psasir.upm.edu.my/id/eprint/85464
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