Citation
Abdullahi, Sharif Alhassan and Unyah, Ngah Zasmy and Nordin, Noshariza and Basir, Rusliza and Mohammed Nasir, Wana and Ahmad Alapid, Ashraf and Hassan, Yahaya and Mustapha, Tijjani and Abd Majid, Roslaini
(2019)
Therapeutic targets on toxoplasma gondii parasite in combatting toxoplasmosis.
Annual Research & Review in Biology, 32 (2).
pp. 1-15.
ISSN 2347-565X
Abstract
The status of toxoplasmosis management is challenged by drug intolerance, compromised efficacy and potential development of drug resistance. However, currently, there are very limited targets on T. gondii that serve as the site of action of current medications. This review aimed to explore more potential targets that are essential to parasite survival and are absent in humans. Many unexplored targets on T. gondii exist and their specificities to the parasite make them ideal drug targets. The present review had searched relevant English databases such as PubMed, Scopus, Google scholar and Science Direct, for relevant literature on the therapeutic target of T. gondii. Many of the enzyme systems in several pathways are essentially palatable as drug targets. Establishing compounds that can target these enzymes on T. gondii will greatly be beneficial in treating acute and chronic toxoplasmosis in humans.
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