Citation
Mohamed Shamaun, Shireen Shaharina
(2008)
Chemical constituents and biological activity of Artocarpus altilis (Moraceae) and Micromelum minutum (Rutaceae).
Masters thesis, Universiti Putra Malaysia.
Abstract
The species of Artocarpus altitis from the Moraceae family and Micromelum minutum
from the Rutaceae family were phytochemically studied and screened for their biological
activities. The first species, Artocarpus altitis (Parkinson) Fosberg was collected from
Kelantan and Pahang. Micromelum Minutum (G. Forst.) Wight & Am. was collected
from Sepilok, Sabah. The crude extracts and isolated compounds were screened for
antimicrobial, cytotoxic and antioxidant activities using disc diffusion method, 1, 2-Diphenyl-2-picrylhydrazyl (DPPH) and Microculture Tetrazolium Salt (MTT) assays
respectively. The microbes used for antimicrobial tests were methicilin resistant
Staphylococcus aureus (MRSA), Bacillus subtilis and Pseudomonas aeruginosa.Detail study on the bark of Artocarpus altilis afforded cycloartocarpin (51), artocarpin
(52), morusin (53), cycloartobiloxanthone (54) and artoindonesianin V (55). Chemical
investigation on the root of Artocarpus altilis have resulted in the isolation of two new
flavonoids, hydroxyartocarpin (56) and artocarpinin (57). Urs-12-en-3β-ol (58) and 6-
methyl-β-D-glucopyranose (60) were isolated from the leaves of Micromelum minutum
along with a coumarin known as 8-hydroxyisocapnolactone-2', 3'-diol (59).
The leaves crude extract of Micromelum minutum gave strong cytotoxic activity towards
HL 60 cell line and exhibited free radical scavenging activity towards DPPH. However,
no activity was observed in the crude extract of Artocarpus altilis.
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