Citation
Abstract
Chitosan is a biodegradable, non-toxic polysaccharide that is extensively studied as a biocompatible vector for gene and drug delivery. However, the fabrication of chitosan nanoparticle (CNP) is usually encountered with a wide size distribution and poor particle stability, which unfortunately limits their role for certain biological applications. This study reports the synthesis and characterisation of CNPs under optimised conditions. The CNPs were synthesised via ionic gelation process utilizing tripolyphosphate (TPP) as a cross-linking agent. The particle size and morphology of samples were subsequently evaluated using dynamic light scattering (DLS), electron microscopy and Fourier-transform infrared spectroscopy (FTIR). Findings arising from this study showed the optimised nanoparticles exhibited spherical shaped CNPs with a size range from 4 to 25nm which lays the foundation for further applications.
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Official URL or Download Paper: http://www.msmbb.my/index.php/volume-27-2019
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Biotechnology and Biomolecular Sciences Faculty of Veterinary Medicine Institute of Bioscience |
| DOI Number: | https://doi.org/10.35118/apjmbb.2019.027.4.09 |
| Publisher: | Malaysian Society for Molecular Biology and Biotechnology, Universiti Putra Malaysia |
| Keywords: | Chitosan nanoparticles; Dynamic light scattering; Fourier-transform infrared spectroscopy; Transmission electron microscope |
| Depositing User: | Mr. Sazali Mohamad |
| Date Deposited: | 11 Aug 2021 06:19 |
| Last Modified: | 11 Aug 2021 06:19 |
| Altmetrics: | http://www.altmetrics.com/details.php?domain=pasir.upm.edu.my&doi=10.35118/apjmbb.2019.027.4.09 |
| URI: | http://psasir.upm.edu.my/id/eprint/82331 |
| Statistic Details: | View Download Statistic |
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