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Recent advancement of engineering microbial hosts for the biotechnological production of flavonoids


Azman Shah, Fatin Lyana and Ramzi, Ahmad Bazli and Baharum, Syarul and Mohd Noor, Normah and Goh, Hoe Han and Leow, Thean Chor and Oslan, Siti Nurbaya and Sabri, Suriana (2019) Recent advancement of engineering microbial hosts for the biotechnological production of flavonoids. Molecular Biology Reports, 46 (11). pp. 6647-6659. ISSN 0301-4851; ESSN: 1573-4978


Flavonoids are polyphenols that are important organic chemicals in plants. The health benefits of flavonoids that result in high commercial values make them attractive targets for large-scale production through bioengineering. Strategies such as engineering a flavonoid biosynthetic pathway in microbial hosts provide an alternative way to produce these beneficial compounds. Escherichia coli, Saccharomyces cerevisiae and Streptomyces sp. are among the expression systems used to produce recombinant products, as well as for the production of flavonoid compounds through various bioengineering approaches including clustered regularly interspaced short palindromic repeats (CRISPR)-based genome engineering and genetically encoded biosensors to detect flavonoid biosynthesis. In this study, we review the recent advances in engineering model microbial hosts as being the factory to produce targeted flavonoid compounds.

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Additional Metadata

Item Type: Article
Divisions: Faculty of Biotechnology and Biomolecular Sciences
DOI Number: https://doi.org/10.1007/s11033-019-05066-1
Publisher: Springer
Keywords: Flavonoid; Metabolic engineering; Escherichia coli; Saccharomyces cerevisiae; Streptomyces sp.
Depositing User: Mr. Sazali Mohamad
Date Deposited: 29 Sep 2021 01:52
Last Modified: 29 Sep 2021 01:52
Altmetrics: http://www.altmetrics.com/details.php?domain=pasir.upm.edu.my&doi=10.1007/s11033-019-05066-1
URI: http://psasir.upm.edu.my/id/eprint/81938
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