Citation
Azman Shah, Fatin Lyana and Ramzi, Ahmad Bazli and Baharum, Syarul and Mohd Noor, Normah and Goh, Hoe Han and Leow, Thean Chor and Oslan, Siti Nurbaya and Sabri, Suriana
(2019)
Recent advancement of engineering microbial hosts for the biotechnological production of flavonoids.
Molecular Biology Reports, 46 (11).
pp. 6647-6659.
ISSN 0301-4851; ESSN: 1573-4978
Abstract
Flavonoids are polyphenols that are important organic chemicals in plants. The health benefits of flavonoids that result in high commercial values make them attractive targets for large-scale production through bioengineering. Strategies such as engineering a flavonoid biosynthetic pathway in microbial hosts provide an alternative way to produce these beneficial compounds. Escherichia coli, Saccharomyces cerevisiae and Streptomyces sp. are among the expression systems used to produce recombinant products, as well as for the production of flavonoid compounds through various bioengineering approaches including clustered regularly interspaced short palindromic repeats (CRISPR)-based genome engineering and genetically encoded biosensors to detect flavonoid biosynthesis. In this study, we review the recent advances in engineering model microbial hosts as being the factory to produce targeted flavonoid compounds.
Download File
Additional Metadata
Actions (login required)
|
View Item |