Citation
Azman, Adleen and Vasodavan, Kalidasan and Sither Joseph Vesudian, Narcisse Mary and Subbiah, Suresh Kumar and Awang Hamat, Rukman and Amin Nordin, Syafinaz and Wan Kamaruddin, Wan Mohd Aizat and Van Belkum, Alex and Neela, Vasantha Kumari
(2019)
Physiological and proteomic analysis of Stenotrophomonas maltophilia grown under the iron-limited condition.
Future Microbiology, 14 (16).
art. no. https://www.futuremedicine.com/toc/fmb/14/16.
ISSN 1746-0921
Abstract
Aims: to study physiological and proteomic analysis of Stenotrophomonas maltophilia grown under iron-limited condition. Methods: one clinical and environmental S. maltophilia isolates grown under iron-depleted conditions were studied for siderophore production, ability to kill nematodes and alteration in protein expression using isobaric tags for relative and absolute quantification (ITRAQ). Results & conclusions: siderophore production was observed in both clinical and environmental strains under iron-depleted conditions. Caenorhabditis elegans assay showed higher killing rate under iron-depleted (96%) compared with normal condition (76%). The proteins identified revealed, 96 proteins upregulated and 26 proteins downregulated for the two isolates under iron depletion. The upregulated proteins included several iron acquisition proteins, metabolic proteins and putative virulence proteins.
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