Citation
Abstract
Phoenix dactylifera L. (date palm) is an essential agricultural crop in many arid regions of the world and has been used in traditional medicine to treat illnesses. Extracts of P. dactylifera are reported to possess valuable pharmacological attributes. This study aims to evaluate the metabolite profiles of date pulp and seeds utilizing 1H nuclear magnetic resonance (NMR) and ultra-high performance liquid chromatography mass spectrometry (UHPLC-MS) techniques. The nitric oxide (NO) inhibitory activity of extracts were assessed using stimulated RAW 264.7 cells along with the NO and DPPH scavenging activities, and total phenolic contents (TPC). Multivariate data analysis (MVDA) was used to examine the similarities and variation between samples of date palms. Principal component analysis (PCA) score plots showed distinct clustering of date seeds and pulp. Examination of the S-plot analysis revealed that ascorbic acid, catechin and glucose were the metabolites that significantly discriminated the date pulp group from the seed group. The seeds of Deglet dates demonstrated significantly higher NO inhibitory and DPPH scavenging activities, with IC50 values of 107.99 μg/mL and 12.58 μg/mL, respectively. The metabolites that prominently contributed to the observed bioactivities included catechin, ascorbic acid and serine. The proposed metabolic pathway indicated that higher amounts of several metabolites are present in date seeds than in date pulp. The presented data suggest possible applications of seeds and pulp of P. dactylifera that may increase the productivity of this fruit crop.
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Additional Metadata
Item Type: | Article |
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Divisions: | Faculty of Food Science and Technology Faculty of Medicine and Health Science Faculty of Science |
DOI Number: | https://doi.org/10.1016/j.phytol.2019.03.004 |
Publisher: | Elsevier |
Keywords: | Phoenix dactylifera; Deglet dates; Metabolomics; Date seeds; Date pulps; Nitric oxide |
Depositing User: | Ms. Nida Hidayati Ghazali |
Date Deposited: | 14 Jun 2021 14:24 |
Last Modified: | 14 Jun 2021 14:24 |
Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.phytol.2019.03.004 |
URI: | http://psasir.upm.edu.my/id/eprint/81337 |
Statistic Details: | View Download Statistic |
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