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Compaction behaviour and mechanical characteristics of chewable binary tablet mixture containing lactose (Flowlac 100) and date (Phoenix dactylifera) powders


Citation

Ahmad Hamidi, Fara Wahida and Anuar, Mohd Shamsul and Samsu Baharuddin, Azhari and P. Mohammed, Mohd Afandi and Naim, Mohd Nazli and Mohd Tahir, Suraya (2019) Compaction behaviour and mechanical characteristics of chewable binary tablet mixture containing lactose (Flowlac 100) and date (Phoenix dactylifera) powders. International Journal of Research in Pharmaceutical Sciences, 10 (4). pp. 3385-3391. ISSN 0975-7538

Abstract

This study aimed to develop a formulation for a chewable tablet using date powder (DP) and Flowlac 100 utilizing a direct compression method. The powders were compacted as single and binary mixtures at five different formulations (DPL1, DPL2, DPL3, DPL4 and DPL5) to study their compaction behaviour. Stressor ranging from 15 to 74 MPa in a cylindrical die with flat face punches were introduced during the fabrication process, and the mechanical properties (plastic work, elastic work and tensile strength) of formed tablets were investigated. Findings of this study demonstrated that with a high percentage of DP in the formulation resulted in a high reading of plastic work, while a low amount of DP revealed low elastic work. Tensile strength of the tablet, on the other hand, varies with the percentage of DP present and applied pressure used. Formulation with 60% DP (DPL4) displayed the highest tensile strength compared to the other formulations, and it is coherent with industrial preferable tensile strength limit. In conclusion, the current findings could be useful in formulation and fabricating date chewable tablet which can be used as a food supplement by all categories of consumers since it is easy to be consumed by a wide range of age.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Engineering
DOI Number: https://doi.org/10.26452/ijrps.v10i4.1648
Publisher: JK Welfare & Pharmascope Foundation
Keywords: Binary mixture; Compaction; Date powder; Elastic work; Flowlac 100; Plastic work
Depositing User: Ms. Nuraida Ibrahim
Date Deposited: 14 Oct 2020 20:02
Last Modified: 14 Oct 2020 20:02
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.26452/ijrps.v10i4.1648
URI: http://psasir.upm.edu.my/id/eprint/80963
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