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Indigenous marine diatoms as novel sources of bioactive peptides with antihypertensive and antioxidant properties


Citation

Barkia, Ines and Al‐Haj, Lamya and Abdul Hamid, Azizah and Zakaria @ Ya, Muta Harah and Saari, Nazamid and Zadjali, Fahad (2019) Indigenous marine diatoms as novel sources of bioactive peptides with antihypertensive and antioxidant properties. International Journal of Food Science and Technology, 54 (5). pp. 1514-1522. ISSN 0950-5423; ESSN: 1365-2621

Abstract

Several bioactive compounds from microalgae have demonstrated diverse biological activities with positive effects on human health. However, the potential of bioactive peptides as functional foods is still undervalued. Therefore, the exploration of microalgae strains as sources of bioactive peptides could reveal strong and unique bioactivities, especially when these marine sources have never been explored before. For this aim, protein extracts from six indigenous marine diatoms were subjected to enzymatic hydrolysis using four proteases (flavourzyme, pepsin, papain and trypsin). The hydrolysates were then tested for angiotensin converting enzyme (ACE)-inhibitory, antioxidant and antihypertensive properties. Results showed that papain hydrolysates from all microalgae strains exhibited strong ACE-inhibitory activities and antioxidant properties. In particular, protein hydrolysates from Bellerochea malleus were found to reduce blood pressure properties of 17 mmHg after 5 days of oral administration to SHR animals. These results revealed the potential of bioactive peptides from indigenous marine diatoms for use as functional foods or nutraceuticals.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Agriculture
Faculty of Food Science and Technology
DOI Number: https://doi.org/10.1111/ijfs.14006
Publisher: Wiley-Blackwell Publishing
Keywords: ACE-inhibitory activity; Antihypertensive activity; Antioxidant activity; Marine microalgae; Protein hydrolysates
Depositing User: Azhar Abdul Rahman
Date Deposited: 19 Oct 2020 16:11
Last Modified: 19 Oct 2020 16:11
Altmetrics: http://altmetrics.com-details.php?domain=psair.upm.edu.my&doi=10.1111/ijfs.14006
URI: http://psasir.upm.edu.my/id/eprint/80239
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