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The myth and therapeutic potentials of postbiotics


Foo, Hooi Ling and Loh, Teck Chwen and Abdul Mutalib, Nur Elina and Abdul Rahim, Raha (2019) The myth and therapeutic potentials of postbiotics. In: Microbiome and Metabolome in Diagnosis, Therapy, and other Strategic Applications. Academic Press, London, 201 - 214. ISBN 9780128152492


Postbiotics (bioactives) are nonviable metabolites produced by probiotics that exert biological effects on the hosts. The myriad beneficial effects of postbiotics produced by six novel bacteriocinogenic Lactobacillus plantarum strains have been proven extensively since 2004, with the broad bacteriocin inhibitory activity against various pathogens, as they harbor two classes of bacteriocin structural genes (plnEF and pln W). The supplementation of the postbiotics to various animal models has significantly improved serum cholesterol, immune response, overall health, and growth, while suppressing the population of pathogenic bacteria in the digestive tract. Additionally, the postbiotics of these lactobacilli strains demonstrated novel antiproliferation and anticancer activity against various human cancer cell lines by inducing cytotoxicity via apoptotic pathway.

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Additional Metadata

Item Type: Book Section
Divisions: Faculty of Agriculture
Faculty of Biotechnology and Biomolecular Sciences
Institute of Bioscience
Institute of Tropical Agriculture and Food Security
DOI Number: https://doi.org/10.1016/B978-0-12-815249-2.00021-X
Publisher: Academic Press
Keywords: Antiproliferation; Antibiotic growth promoter; Cytotoxicity; Food additives; Lactobacillus plantarum; Postbiotic
Depositing User: Azhar Abdul Rahman
Date Deposited: 03 Aug 2021 10:01
Last Modified: 03 Aug 2021 10:01
Altmetrics: http://altmetrics.com-details.php?domain=psair.upm.edu.my&doi=10.1016/B978-0-12-815249-2.00021-X
URI: http://psasir.upm.edu.my/id/eprint/78995
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