Citation
Abdul Rahman, Mohd Basyaruddin and Jaafar, Ahmad Haniff and Basri, Mahiran and Raja Abdul Rahman, Raja Noor Zaliha and Salleh, Abu Bakar and Abdul Wahab, Habibah
(2007)
Design of novel semisynethetic metalloenzyme from thermolysin.
In: BioSysBio 2007: Systems Biology, Bioinformatics, Synthetic Biology, 11-13 Jan. 2007, Manchester, UK. .
Abstract
Initial applications of biocatalysis involved the used of
naturally occurring enzyme. With new challenges in green
chemical reaction, biocatalyst that shed the light is metalloenzyme,which function as enzyme and contain metal
that are tightly attached and always isolated with the protein[1]. In recent years, enzyme engineering has proven to be an invaluable tool for elucidating biocatalytic mechanisms as well as producing enzymes for industrial purposes.Approaches developed for in vivo chemical
modification and in silico computational methods promise
to increase the scope and have already been used successfully to alter existing protein so that they have better stability and functionality [2]. This task might be good to address in designing a new biocatalyst with improved
properties.
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