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Boer goats appear to lack a functional IgA and eosinophil response against natural nematode infection


Citation

Md Isa, Nur Mahiza and Basripuzi, N. Hayyan and Salisi, Mohd Shahrom and Busin, Valentina and Cairns, Callum and Jenvey, Caitlin and Stear, Michael J. (2018) Boer goats appear to lack a functional IgA and eosinophil response against natural nematode infection. Veterinary Parasitology, 264. 18 - 25. ISSN 0304-4017; ESSN: 1873-2550

Abstract

Gastrointestinal nematode infection is one of the major diseases affecting small ruminants. Although some breeds of goats are quite resistant, many breeds of goats are relatively susceptible. This study used a combined parasitological, immunological, bioinformatic and statistical approach to examine the role of goat IgA and eosinophils in protection against Teladorsagia circumcincta. Molecular modelling suggested that the transmembrane domain of the high affinity IgA receptor was dysfunctional in goats. Statistical analyses failed to find any association in naturally infected goats between high IgA or eosinophil responses and low faecal egg counts. Together these results indicate that IgA and eosinophil responses against T. circumcincta are less effective in goats than sheep.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Veterinary Medicine
DOI Number: https://doi.org/10.1016/j.vetpar.2018.10.014
Publisher: Elsevier
Keywords: Sheep; Nematode; Teladorsagia circumcincta; Immune response; IgA; Eosinophil
Depositing User: Ms. Nuraida Ibrahim
Date Deposited: 30 Nov 2020 08:23
Last Modified: 30 Nov 2020 08:23
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1016/j.vetpar.2018.10.014
URI: http://psasir.upm.edu.my/id/eprint/73295
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