Citation
Kusumaningtyas, Eni and Tan, Wen Siang and Zamrod, Zulkeflie and Eshaghi, Majid and Yusoff, Khatijah
(2004)
Existence of Two Form of L Protein of Newcastle Disease Virus Isolates Due to a Compensatory Mutation in Domain V.
Archives of Virology, 149 (1).
pp. 1859-1865.
ISSN 0304-8608
Abstract
Summary. Nucleotide sequence comparison of the L gene of the Malaysian neurotropic-viscerotropic velogenic NDV strain AF2240 with other NDV strains revealed a single nucleotide insertion at position 3870. This mutation is compensated by a nucleotide deletion downstream at position 3958 which results in two forms of the L proteins containing a 30-amino acid substitution in Domain V. This compensatory mutation this does not correlate with the pathogenicity of the viral strains but is may affect the viral replication as Domain V is believed to play an important role in the replication of paramyxoviruses.
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Official URL or Download Paper: http://dx.doi.org/10.1007/s00705-004-0336-5
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Biotechnology and Biomolecular Sciences |
| Publisher: | Springer Wien |
| Depositing User: | Users 17 not found. |
| Date Deposited: | 24 Nov 2008 15:58 |
| Last Modified: | 27 May 2013 06:50 |
| Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1007/s00705-004-0336-5 |
| URI: | http://psasir.upm.edu.my/id/eprint/693 |
| Statistic Details: | View Download Statistic |
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