Citation
Abdul Aziz, Nur Fadhilah
(2016)
Synthesis, characterization and cytotoxic study of Cu(II) and Ni(II) containing amino acid derived schiff bases.
Masters thesis, Universiti Putra Malaysia.
Abstract
Thirty new metal complexes were synthesized from the reaction of Cu(II) acetate and
Ni(II) nitrate with Schiff bases derived from the condensation of amino acids (Lphenylalanine,
L-valine and glycine) and different heterocyclic aldehydes and
ketones. The complexes were characterized by elemental analysis and conductance,
magnetic, IR and electronic spectroscopic measurements. The data obtained
indicated that the amino acid derived Schiff bases behaved as uninegatively charged
bidentate ligands and coordinated with the Cu(II) and Ni(II) ions through their
azomethine nitrogen and the deprotonated carboxylate oxygen yielding stable metal
complexes as evidenced in their IR spectra. In most of the Cu(II) complexes, only
one amino acid derived Schiff base coordinated to the metal centre, while the third
and fourth position were occupied by a bidentate -OO- acetate anion. Whereas in two
other Cu(II) complexes ([Cu(ph3t)2].H2O (Cu(II) complex of 2-[(3-methylthiophene-
2-ylmethylene)-amino]-3-phenyl-propionic acid) and [Cu(glypy)2].5H2O (Cu(II)
complex of [1-(1H-Pyrrol-2-yl)-ethylideneamino]-acetic acid)) and all the Ni(II)
complexes, two bidentate -ON- amino acid derived Schiff bases were bonded to the
metal centre. Magnetic and spectral evidence supported a four-coordinate geometry
for all complexes synthesized. The thermal analysis studies proved the presence of
water molecules and methanol outside the inner coordination sphere of some of the
complexes synthesized. In turn, the cytotoxic activities of the metal complexes were
evaluated against two bladder cancer cell lines which are EJ-28 (invasive human
bladder cancer cell line) and RT-112 (minimally-invasive human bladder cancer cell
line) and ten of the Ni(II) complexes showed remarkable cytotoxicity against EJ-28
cells while six of the Cu(II) complexes were found to be cytotoxic against RT-112
cells. In conclusion, it appeared that the complexes derived from glycine and 2-
acetylpyrrole as their ligands had the best cytotoxic activity in both cancer cell lines.
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