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Targeted delivery of doxorubicin-loaded cockle shell-derived CaCO3 aragonite nanoparticles on dog bearing tumour


Citation

Danmaigoro, Abubakar and Selvarajah, Gayathri Thevi and Mohd Noor, Mohd Hezmee and Mahmud, Rozi and Ahmed, Hamidu and Abu Bakar @ Zakaria, Md Zuki (2018) Targeted delivery of doxorubicin-loaded cockle shell-derived CaCO3 aragonite nanoparticles on dog bearing tumour. In: 2nd International Symposium on Advanced Materials and Nanotechnology (i-SAMN 2018), 15-16 Aug. 2018, The Everly Putrajaya, Malaysia. (pp. 48-49).

Abstract

The treatment of solid tumour remains a major challenge to oncologist, even when chemotherapy is referred as the best treatment option, with doxorubicin widely used but it application is impaired in its high concentration levels resulting tissue injury. Cockle shell-derived calcium carbonate nanoparticle-loaded with DOX (CS-CaCO3NP-DOX) has shown a promising potential in the pre-clinical studies. This trial is aimed at exploring the effectiveness of CS-CaCO3NP-DOX on dogs bearing tumour. A non-blinded open clinic trial of CSCaCO3NP-DOX on dogs with solid tumour. The primary and secondary endpoints were evaluated every 3 weeks for 15 weeks. There was not major adverse effect observed with the formulation. Although, partial response and progressive cRECIST response were recorded in the two cases enrolled. This preliminary finding shows that biogenic CS-CaCO3NP-DOX is potentially effective on treating solid cancer in dog and improves the quality of life of dogs with bearing solid tumour.


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Additional Metadata

Item Type: Conference or Workshop Item (Paper)
Divisions: Faculty of Medicine and Health Science
Faculty of Veterinary Medicine
Institute of Bioscience
Keywords: CS-CaCO3NP; Doxorubicin; Clinical trial; Dog; Tumour
Depositing User: Nabilah Mustapa
Date Deposited: 08 Oct 2018 02:27
Last Modified: 08 Oct 2018 02:27
URI: http://psasir.upm.edu.my/id/eprint/65423
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