The CRISPR growth spurt: from bench to clinic on versatile small RNAs

Citation

Bayat, Hadi and Omidi, Meisam and Masoumeh, Rajabibazl and Rahimpour, Azam and Sabri, Suriana (2017) The CRISPR growth spurt: from bench to clinic on versatile small RNAs. Journal of Microbiology and Biotechnology, 27 (2). pp. 207-218. ISSN 1017-7825; ESSN: 1738-8872

Abstract

Clustered Regulatory Interspaced Short Palindromic Repeats (CRISPR) in association with CRISPR associated protein (Cas) is an adaptive immune system, playing a pivotal role in the defense of bacteria and archaea. Ease of handling and cost effectiveness make CRISPR-Cas system an ideal programmable nuclease tool. Recent advances in understanding the CRISPR-Cas system have tremendously improved its efficiency. For instance, it is possible to recapitulate the chronicle CRISPR-Cas from its infancy and inaugurate a developed version by generating novel variants of Cas proteins, subduing off-target effects and optimization of innovative strategies. In summary, CRISPR-Cas system could be employed in a number of applications including providing model systems, rectification of detrimental mutations, and antiviral therapies.

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Additional Metadata

Item Type:	Article
Divisions:	Faculty of Biotechnology and Biomolecular Sciences
DOI Number:	https://doi.org/10.4014/jmb.1607.07005
Publisher:	Korean Society for Microbiology and Biotechnology
Keywords:	CRISPR-Cas system; DNA repair; Adoptive immunity; Genome editing
Depositing User:	Mas Norain Hashim
Date Deposited:	19 Jul 2018 02:18
Last Modified:	19 Jul 2018 02:18
Altmetrics:	http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.4014/jmb.1607.07005
URI:	http://psasir.upm.edu.my/id/eprint/63418
Statistic Details:	View Download Statistic

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