Citation
Chiroma, Samaila Musa and Mohd Moklas, Mohamad Aris and Mat Taib, Che Norma and Baharuldin, Mohamad Taufik Hidayat and Jagadeesan, Saravanan and Amom, Zulkhairi and Ibrahim, Bulama
(2017)
Neuro-therapeutic benefits of Centella asiatica on some neurodegenerative diseases: a review.
Research Journal of Pharmaceutical, Biological and Chemical Sciences, 8 (6).
549 - 556.
ISSN 0975-8585
Abstract
Medicinal herbalism has become popular because of its documented efficacy, synergistic interactions against complex conditions and lesser side effects. CA (CA) is a traditional Ayurveda medicine widely used in India, China, and Malaysia and across countries in south-eastern Asia for treating a range of diseases. The whole plant or its parts (leaf or roots) are used for medicinal purpose and its chemical constituents have been proven scientifically to have neuro-protective, wound healing, anti-inflammatory and antioxidants activities. In this review we have retrieved and evaluated available literatures on neuro-therapeutic properties of CA on neurotoxic and transgenic models of Alzheimer’s diseases (AD), Parkinson’s disease (PD) and Huntington’s disease (HD). The extract was found to have neuroprotective ability through modifying a key signaling pathways and events concerned with neuro-degeneration. Further research is required to discover more bioactive compounds of CA and their exact mode of action.
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