Citation
Arieef, Mohd Fahmi and Kasim, Shahreen and Yee, Wen Choon and Mohamad, Mohd Saberi and Deris, Safaai and Napis, Suhaimi and Kasim, Shahreen
(2017)
A hybrid of integer differential bees and flux balance analysis for improving succinate and lactate production.
International Journal on Advanced Science, Engineering and Information Technology, 7 (4-2).
1615 - 1620.
ISSN 2088-5334; ESSN: 2460-6952
Abstract
The production of succinate and lactate from E.coli become a demand in pharmaceutical industries. To increase the yield of the production, gene knockout technique was implemented in various hybrid optimization algorithms. In recent years, several hybrid optimization have been introduced to optimize succinate and lactate production. However, the previous works were ineffective to produce the highest production due to the size and complexity of metabolic networks and the dynamic interaction between the components. Therefore, the main purpose of this study is to overcome the limitation of the existing algorithms which hybridizing Integer Differential Bees and Flux Balance Analysis (IDBFBA). The experimental results show a better performance in terms of growth rate and production yield of desired phenotypes compared to the method used in previous works.
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