Citation
Idris, Ibrahim Mu'awiyya and Abu Bakar, Mohd Rizam
(2015)
Effect of tumor microenvironmental factors on the stability of tumor growth dynamics with nonzero correlation time.
In: 2nd International Conference on Computing, Mathematics and Statistics (iCMS 2015), 4-5 Nov. 2015, Langkawi, Kedah. (pp. 137-144).
Abstract
The effect of tumor microenvironmental factors on tumor growth dynamics modeled by multiplicative colored noise is investigated. Using the Novikov theorem and Fox approach, an approximate Fokker--Planck equation for the non-Markovian stochastic equation is obtained and an analytic expression for the steady-state probability distribution Pst(x) is derived. We found that the strength of the microenvironmental factors θ have a negative effect on the stability of tumor growth at weak correlation time τ and at strong correlation time, the effect of θ is opposed and instead a positive growth stability is noticed for the tumor growth dynamics which in other words corresponds to growth effect. The result indicated that the growth effect exerted by the non-immunogenic components of tumor microenvironmental depend on the strength of the correlation time τ.
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Effect of tumor microenvironmental factors on the stability of tumor growth dynamics with nonzero correlation time.pdf
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