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A comparison of dabigatran and warfarin for stroke prevention in elderly Asian population with nonvalvular atrial fibrillation: an audit of current practice in Malaysia


Citation

Yap, Swee Hien and Ng, Yau Piao and Roslan, Aslannif and Jayakhantan, Kolanthaivelu and Koh, Kok Wei and P'ng, Hon Shen and Boo, Yang Liang and Hoo, Fan Kee and Yap, Lok Bin (2017) A comparison of dabigatran and warfarin for stroke prevention in elderly Asian population with nonvalvular atrial fibrillation: an audit of current practice in Malaysia. Medical Journal of Malaysia, 72 (6). pp. 360-364. ISSN 0300-5283

Abstract

Introduction: Atrial fibrillation (AF) is the most common cardiac arrhythmia with significant morbidity and mortality in relation to thromboembolic stroke. Our study aimed to evaluate the safety and efficacy of dabigatran in stroke prevention in elderly patient with nonvalvular AF with regard to the risk of ischemic stroke and intracranial haemorrhage (ICH) in real-world setting. Methods: A retrospective cohort study of 200 patients on dabigatran and warfarin from January 2009 till September 2016 was carried out. Data were collected for 100 patients on dabigatran and 100 patients on warfarin. Results: The mean follow-up period was 340.7±322.3 days for dabigatran group and 410.5±321.2 days for warfarin group. The mean time in therapeutic range (TTR) was 52±18.7%. The mean CHA2DS2 -VASc score for dabigatran group was 4.4±1.1 while 5.0±1.5 for warfarin group. None in dabigatran group experienced ischemic stroke compared to one patient in warfarin group (p=0.316). There was one patient in dabigatran group suffered from ICH compared to none in warfarin group (p=0.316). Four patients in warfarin group experienced minor bleeding, while none from dabigatran group (p=0.043). Conclusion: Overall bleeding events were significantly lower in dabigatran group compared to warfarin group. In the presence of suboptimal TTR rates and inconveniences with warfarin therapy, non-vitamin-K antagonist oral anticoagulants (NOAC) are the preferred agents for stroke prevention in elderly Asian patients for nonvalvular AF.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: Malaysia Medical Association
Keywords: Atrial fibrillation; Dabigatran; Warfarin; Stroke prevention; Bleeding events
Depositing User: Nabilah Mustapa
Date Deposited: 09 Mar 2018 07:02
Last Modified: 09 Mar 2018 07:02
URI: http://psasir.upm.edu.my/id/eprint/59575
Statistic Details: View Download Statistic

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