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A brief review on free light chain assays: from conventional to current


Citation

Zahari Sham, Siti Yazmin and Chellappah Thambiah, Subashini and Samsudin, Intan Nureslyna (2017) A brief review on free light chain assays: from conventional to current. Malaysian Journal of Medicine and Health Sciences, 13 (2). pp. 59-62. ISSN 1675-8544

Abstract

Free light chains (FLCs) are tumour markers of monoclonal gammopathies. Detection of urinary FLC or also known as Bence-Jones protein through urinary protein and its immunofixation electrophoreses (UPE and uIFE, respectively) have been considered the gold standard for its biochemical diagnosis. This is mainly due to their superior detection limits compared to their counterpart investigations in serum. However, urinalysis is limited in many ways. The emergence of serum FLC assay with markedly improved detection limit circumvents many of these problems and has gained much importance in biochemical investigations of monoclonal gammopathies. Nevertheless, they are not without limitations. This review discusses the advantages and limitations of serum and urinary FLC assays.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Medicine and Health Science
Publisher: Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
Keywords: Free light chain; Monoclonal gammopathies; Urine protein electrophoresis; Serum free light chain assay
Depositing User: Nabilah Mustapa
Date Deposited: 05 Jan 2018 03:15
Last Modified: 26 Jan 2018 09:47
URI: http://psasir.upm.edu.my/id/eprint/58284
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