Citation
Abstract
The crude petroleum ether and chloroform extracts of Micromelum minutum (G. Frost.) Wright & Arn (Rutaceae) showed strong cytotoxic activity when tested against a T-lymphoblastic leukemia cell line. Further fractionation of the extracts resulted in the isolation of five new coumarins 3″,4″-dihydrocapnolactone, 2′,3′-epoxyisocapnolactone, 8-hydroxyisocapnolactone-29,39-diol, 8-hydroxy-3″,4″- dihydrocapnolactone-29,39-diol and 8,4″-dihydroxy-3″,4″- dihydrocapnolactone-29,39-diol, and two triterpenes. Some of these compounds were strongly active against T-lymphoblastic leukemia (CEM-SS), promyeolocytic leukemia (HL60), cervical cancer (HeLa) and liver cancer (HepG2) cell lines. 8-Hydroxyisocapnolactone-29,39-diol was found to be the most active with IC50 values of 2.9, 2.5, 6.9, and 5.9 μg/ml, respectively. This was followed by 2′,3′-epoxyisocapnolactone. When evaluated against the normal mouse fibroblast (3T3) cell line, 8-hydroxyisocapnolactone-29,39-diol was found to be inactive, hence it could serve as a valuable lead for further design and synthesis of more active analogues.
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Official URL or Download Paper: http://www.tandfonline.com/doi/abs/10.1080/1388020...
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Biotechnology and Biomolecular Sciences Faculty of Science |
| DOI Number: | https://doi.org/10.1080/13880200802436513 |
| Publisher: | Informa Healthcare |
| Keywords: | 2′,3′-epoxyisocapnolactone; 8-hydroxyisocapnolactone-29,39-diol; Capnolactone; Coumarins; Cytotoxicity; Micromelum minutum; Triterpenes |
| Depositing User: | Nabilah Mustapa |
| Date Deposited: | 04 Jul 2017 02:48 |
| Last Modified: | 04 Jul 2017 02:48 |
| Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1080/13880200802436513 |
| URI: | http://psasir.upm.edu.my/id/eprint/56238 |
| Statistic Details: | View Download Statistic |
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