Citation
Hamidon, Hanisuhana and Taher, Muhammad and Md Jaffri, Juliana and Tg Zakaria, Tg Muhamad Faris Syafiq and Sulaiman, Wan M. A. W. and Susanti, Deny and Ichwan, Solachuddin J. A. and Zakaria, Zainul A.
(2016)
Cytotoxic and anti - inflammatory activities of Garcinia xanthochymus extracts on cell lines.
Makara Journal Health Research, 20 (1).
pp. 11-17.
ISSN 2356-3664; ESSN: 2356-3656
Abstract
Objective: Garcinia xanthochymus extract has been reported to have several pharmacological properties. This study was conducted to evaluate cytotoxic and anti-inflammatory activities of G. xanthochymus extracts on cell lines. Methods: The roots and stem barks of plant were extracted using maceration method with n-hexane, dichloromethane and methanol, successively. Cytotoxic activity of the extracts was tested against MCF-7 breast adenocarcinoma using MTT assay. Anti-inflammatory study was evaluated using RAW 264.7 mouse macrophage cells. The nitric oxide production in LPS-stimulated cells was measured using Griess reagent. Results: The results of cytotoxic and anti-inflammatory study showed that dichloromethane and n-hexane extracts of root and stem bark exhibited cytotoxic activity in dose-dependent manner. Meanwhile, for anti-inflammatory study, all root extracts together with stem bark dichloromethane and n-hexane extracts reduce NO production in LPS-stimulated cells in dose dependent manner. Conclusions: This finding indicated that G. xanthochymus extracts might become interesting candidate for treatment of cancer and inflammation.
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