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Structure–activity relationship study of secondary metabolites from Mesua beccariana, Mesua ferrea and Mesua congestiflora for anti-cholinesterase activity


Citation

Teh, Soek Sin and Cheng, Gwendoline Lian Ee and Mah, Siau Hui and Ahmad, Zuraini (2016) Structure–activity relationship study of secondary metabolites from Mesua beccariana, Mesua ferrea and Mesua congestiflora for anti-cholinesterase activity. Medicinal Chemistry Research, 25 (5). pp. 819-823. ISSN 1054-2523; ESSN: 1554-8120

Abstract

Our search for potential anti-acetylcholinesterase (AChE) inhibitors for treatment of Alzheimer’s disease has led to the discovery of two bioactive compounds, α-mangostin (11) and congestiflorone acetate (13). This discovery was achieved from a preliminary screening of the anti-AChE activity on the extracts of three Mesua species namely M. ferrea, M. beccariana and M. congestiflora using Ellman’s method. The pure metabolites, 1–12 which were isolated from the Mesua species, along with a synthetic derivative, compound 13 were then evaluated for their activities in order to identify the compounds that correspond to the enzyme inhibitory activities. Compounds 11 and 13 were found to give significant anti-AChE activities with IC50 values of 17.51 and 20.25 µM.


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Additional Metadata

Item Type: Article
Subject: Anti-acetylcholinesterase; Mesua ferrea; Mesua beccariana; Mesua congestiflora; α-mangostin; Congestiflorone acetate
Divisions: Faculty of Medicine and Health Science
Faculty of Science
DOI Number: https://doi.org/10.1007/s00044-016-1531-0
Publisher: Springer Verlag
Depositing User: Nurul Ainie Mokhtar
Date Deposited: 21 Feb 2018 03:52
Last Modified: 21 Feb 2018 03:52
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1007/s00044-016-1531-0
URI: http://psasir.upm.edu.my/id/eprint/53914
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