UPM Institutional Repository

Effects of Centella asiatica extract and powder on hydrogen peroxide-treated Sprague-Dawley rats


Citation

Hussin, Mahanom and Abdul Hamid, Azizah and Mohamed, Suhaila and Saari, Nazamid and Ismail, Maznah and Bejo, Mohd Hair (2011) Effects of Centella asiatica extract and powder on hydrogen peroxide-treated Sprague-Dawley rats. Journal of Tropical Agriculture and Food Science, 39 (1). pp. 1-10. ISSN 1394-9829; ESSN: 2289-9650

Abstract

A study was conducted to investigate the effect of Centella asiatica extract and powder on dietary intake, body weight, organ weights and blood lipid peroxidation of hydrogen peroxide (H2O2)-treated male Sprague-Dawley rats. The experimental rats were fed with 0.3% (w/w) C. asiatica extract, 1.5% (w/w) C. asiatica powder, 5.0% (w/w) C. asiatica powder and 0.3% (w/w) a-tocopherol for 6 weeks. To induce oxidative stress, the rats were given drinking water spiked with 0.03% (v/v) H2O2. The amount of dietary intake, organ and body weight, and malonaldehyde (MDA) level throughout the study were monitored. Histopathological examination of selected organs was done at the end of the study. The results showed that MDA level was significantly (p <0.05) higher in the normal rats compared to treated rats. Dietary supplementation of C. asiatica (extract and powder) and a-tocopherol significantly (p <0.05) reduced lipid peroxidation in the experimental rats. However, there were no significant differences in dietary intake and histopathology observations of the organs of the rats.


Download File

[img]
Preview
PDF (Abstract)
Effects of Centella asiatica extract and powder on hydrogen peroxide-treated 45 Sprague-Dawley rats.pdf

Download (36kB) | Preview

Additional Metadata

Item Type: Article
Divisions: Faculty of Food Science and Technology
Faculty of Veterinary Medicine
Institute of Bioscience
Publisher: Malaysian Agricultural Research and Development Institute (MARDI)
Keywords: Centella asiatica; Lipid peroxidation; Malonaldehyde; Hydrogen peroxide; Sprague-Dawley rats
Depositing User: Nabilah Mustapa
Date Deposited: 29 Dec 2016 09:34
Last Modified: 29 Dec 2016 09:34
URI: http://psasir.upm.edu.my/id/eprint/48884
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item