Citation
Akhmad Aznan, Aina Mardia and Abdullah, Zanariah and Khoo, Chai Hoon and Chen, Bao Jing and See, Tian Hong and Sim, Jiun Horng and Cheah, Yoke Kqueen and Seng, Hoi Ling and Tiekink, Edward R.T.
(2015)
Three ammonium salts of sulfathiazole: crystallography and anti-microbial assay.
Zeitschrift Fur Kristallographie-New Crystal Structures, 230 (6).
pp. 385-396.
ISSN 1433-7266; ESSN: 2197-4578
Abstract
The crystal and molecular structures of three ammonium salts derived from sulfathiazole are described. In each case, the anion is in the azanide form, features an intramolecular S←O interaction, and adopts a U-shape. The structures of two cations, [R(HOCH2CH2)NH2]+, namely for R = Me (1) and iPr (2), are unprecedented in the crystallographic literature. Extensive hydrogen bonding is observed in all crystal structures and leads to a two-dimensional array for 1, and three-dimensional architectures for each of 2 and 3 (R = CH2CH2OH). The salts exhibited anti-microbial activity against a range of Gram-positive and Gram-negative bacteria, and proved bactericidal toward Vibrio parahaemolyticus, but had no advantage over sulfathiazole itself.
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