The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling

Citation

Engström, Wilhelm and Darbre, Philippa and Eriksson, Staffan and Gulliver, Linda and Hultman, Tove and Karamouzis, Michalis V. and Klaunig, James E. and Mehta, Rekha and Moorwood, Kim and Sanderson, Thomas and Sone, Hideko and Vadgama, Pankaj and Wagemaker, Gerard and Ward, Andrew and Singh, Neetu and Al-Mulla, Fahd and Al-Temaimi, Rabeah and Amedei, Amedeo and Colacci, Anna Maria and Vaccari, Monica and Mondello, Chiara and Scovassi, A. Ivana and Raju, Jayadev and Abd. Hamid@ Abd. Razak, Roslida and Memeo, Lorenzo and Forte, Stefano and Roy, Rabindra and Woodrick, Jordan and Salem, Hosni K. and Ryan, Elizabeth P. and Brown, Dustin G. and Bisson, William H. (2015) The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling. Carcinogenesis, 36 (suppl.). pp. 38-60. ISSN 0143-3334; ESSN: 1460-2180

Abstract

The aim of this work is to review current knowledge relating the established cancer hallmark, sustained cell proliferation to the existence of chemicals present as low dose mixtures in the environment. Normal cell proliferation is under tight control, i.e. cells respond to a signal to proliferate, and although most cells continue to proliferate into adult life, the multiplication ceases once the stimulatory signal disappears or if the cells are exposed to growth inhibitory signals. Under such circumstances, normal cells remain quiescent until they are stimulated to resume further proliferation. In contrast, tumour cells are unable to halt proliferation, either when subjected to growth inhibitory signals or in the absence of growth stimulatory signals. Environmental chemicals with carcinogenic potential may cause sustained cell proliferation by interfering with some cell proliferation control mechanisms committing cells to an indefinite proliferative span.

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Additional Metadata

Item Type:	Article
Divisions:	Faculty of Medicine and Health Science
DOI Number:	https://doi.org/10.1093/carcin/bgv030
Publisher:	Oxford University Press
Keywords:	Cancer hallmark
Depositing User:	Ms. Nida Hidayati Ghazali
Date Deposited:	22 Feb 2018 07:40
Last Modified:	22 Feb 2018 07:40
Altmetrics:	http://www.almetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1093/carcin/bgv030
URI:	http://psasir.upm.edu.my/id/eprint/46664
Statistic Details:	View Download Statistic

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