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RCMV ALL-03 model and study of CMV pathogenesis in congenital infection


Citation

Abdullah, Ashwaq Ahmed and Balakrishnan, Krishnan Nair and Abba, Yusuf and Jesse A, Faez Firdaus and Allaudin Nazariah, Zeenathul and Abdullah, Rasedee and M Mustapha, Noordin and Mohd Lila, Mohd Azmi (2015) RCMV ALL-03 model and study of CMV pathogenesis in congenital infection. American Journal of Animal and Veterinary Sciences, 10 (3). pp. 170-186. ISSN 1557-4555; ESSN: 1557-4563

Abstract

Cytomegalovirus (CMV) is one of the most commonly studied members of the Herpesviridae family. So far several strains have been identified but human CMV (HCMV) remains the most important due to its ability to infect humans and also cross the placenta causing neonatal infection and mortality. However, there are several limitations in the study of this strain which includes availability and use of model animals. Although strains such as Rhesus CMV (RhCMV), Guinea pig CMV (GPCMV) and Rat CMV (RCMV ALL-03) have been shown to cross the placenta and exhibit similar pathogenesis to HCMV, only RCMV ALL-03 can be conveniently used without much limitations as guinea pigs are resistant to antiviral drugs, while rhesus monkeys are seropositive, considered costly and have ethical use restrictions. We therefore propose the use of RCMV ALL-03 as a model for the study of CMV infection.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Veterinary Medicine
Institute of Bioscience
DOI Number: https://doi.org/10.3844/ajavsp.2015.170.186
Publisher: Science Publications
Keywords: Cytomegalovirus; Animal model; Congenital infection; Sensory neural hearing defect (SNHD); Central nervous system abnormalitis
Depositing User: Ms. Nida Hidayati Ghazali
Date Deposited: 23 Mar 2022 04:26
Last Modified: 23 Mar 2022 04:26
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.3844/ajavsp.2015.170.186
URI: http://psasir.upm.edu.my/id/eprint/46083
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