UPM Institutional Repository

Phenolic rich extract from Clinicanthus nutans attenuates hyperlipidemia-associated oxidative stress in rats


Citation

Ismail, Maznah and Mohd Esa, Norhaizan and Zawawi, Norhasnida and Sarega, Nadarajan and Imam, Mustapha Umar and Ooi, Der Jiun and Chan, Kim Wei (2015) Phenolic rich extract from Clinicanthus nutans attenuates hyperlipidemia-associated oxidative stress in rats. Oxidative Medicine and Cellular Longevity. pp. 1-16. ISSN 1942-0994; ESSN: 1942-0900

Abstract

Clinacanthus nutans is used as traditional medicine in Asia but there are limited scientific studies to support its use. In this study, the stem and leaf of C. nutans were extracted using solvents of differing polarities, and their antioxidant capacities were determined using multiple antioxidant assays. The water and aqueous methanolic leaf extracts were further fractionated and their antioxidant capacities and phenolic compositions were tested. Furthermore, the efficacies of the water and aqueous methanolic leaf extracts were tested against hyperlipidemia-induced oxidative stress in rats. Serum and hepatic antioxidant and oxidative stress markers were tested after feeding the rats with high fat diet together with the extracts or simvastatin for 7 weeks. The results indicated that both leaf extracts attenuated oxidative stress through increasing serum antioxidant enzymes activity and upregulating the expression of hepatic antioxidant genes. Multiple phenolic compounds were detected in the extracts and fractions of C. nutans, although protocatechuic acid was one of the most abundant and may have contributed significantly towards the bioactivities of the extracts. However, synergistic effects of different phenolics may have contributed to the overall bioactivities. C. nutans can be a good source of functional ingredients for the management of oxidative stress-related diseases.


Download File

[img] Text (Abstract)
NUTAN.pdf

Download (5kB)

Additional Metadata

Item Type: Article
Divisions: Faculty of Food Science and Technology
Faculty of Medicine and Health Science
Institute of Bioscience
DOI Number: https://doi.org/10.1155/2016/4137908
Publisher: Hindawi Publishing Corporation
Keywords: Clinacanthus nutans; Traditional medicine; Antioxidant; Oxidative stress; Rat
Depositing User: Ms. Nuraida Ibrahim
Date Deposited: 25 Jan 2021 17:19
Last Modified: 25 Jan 2021 17:19
Altmetrics: http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.1155/2016/4137908
URI: http://psasir.upm.edu.my/id/eprint/45835
Statistic Details: View Download Statistic

Actions (login required)

View Item View Item