Antilipase and antioxidant activity of Phyllanthus niruri ethanolic extract

Citation

Raja Abdul Rahman, Raja Noor Zaliha and Alias, Norsyuhada and Leow, Adam Thean Chor and Mohamad Ali, Mohd Shukuri and Ahmad Tajudin, Asilah and Salleh, Abu Bakar (2015) Antilipase and antioxidant activity of Phyllanthus niruri ethanolic extract. Australian Journal of Basic and Applied Sciences, 9 (7). pp. 133-136. ISSN 1991-8178

Abstract

The aim of this study is to determine the antilipase and antioxidant activity of Phyllanthus niruri methanolic extract. The inhibitory activity against porcine pancreatic lipase (PPL) was determined by measuring the hydrolysis of p-nitrophenyl butyrate to p-nitrophenol at 405 nm. The crude extract exhibited strong lipase inhibitory activity with an IC50 value of 27. 65 µg/ mL. The inhibition mode study disclosed that P. niruri could act as noncompetitive inhibitor. Antioxidant activity of P. niruri extract was measured by 2, 2, diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity assay. P. niruri showed high antioxidant activity with an EC50 value of 7.471 µg/mL. The results suggested that P. niruri has shown potential as a source of natural antilipase and antioxidant.

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Additional Metadata

Item Type:	Article
Divisions:	Faculty of Biotechnology and Biomolecular Sciences
Publisher:	American-Eurasian Network for Scientific Information
Keywords:	Phyllanthus niruri; Antilipase; Antioxidant; DPPH
Depositing User:	Mohd Hafiz Che Mahasan
Date Deposited:	09 Apr 2018 06:24
Last Modified:	24 Sep 2018 00:47
URI:	http://psasir.upm.edu.my/id/eprint/43793
Statistic Details:	View Download Statistic

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