Citation
Abstract
Purpose: To search for new acetylcholinesterase enzyme inhibitors from Calopyllum species. Methods: Six stem bark extracts of Calophyllum inophyllum, C. soulattri, C. teysmannii, C. lowii, C. benjaminum and C. javanicum were subjected to anti-cholinesterase analysis against acetylcholinesterase (AChE) enzyme using Ellman’s method. Results: Most of the extracts showed promising inhibitory activity against AChE at concentrations of 100 μg/mL, with the methanol extract of C. inophyllum demonstrating the strongest inhibitory effect of 81.28 % followed by the methanol extract of C. benjaminum with 74.32 % inhibition. The methanol extracts of Calophyllum inophyllum and Calophyllum bejaminum also showed significant inhibitory activity towards the acetylcholinesterase (AChE) enzyme. Conclusion: Calophyllum species is capable of yielding potential lead compounds for the development for acetyl-cholinesterase enzyme inhibition drugs.
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Official URL or Download Paper: http://www.bioline.org.br/pdf?pr15262
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Additional Metadata
| Item Type: | Article |
|---|---|
| Divisions: | Faculty of Medicine and Health Science Faculty of Science |
| DOI Number: | https://doi.org/10.4314/tjpr.v14i11.8 |
| Publisher: | Pharmacotherapy Group, Faculty of Pharmacy, University of Benin |
| Keywords: | Calophyllum species; Acetylcholinesterase; Inhibitors |
| Depositing User: | Mohd Hafiz Che Mahasan |
| Date Deposited: | 22 Jul 2016 02:47 |
| Last Modified: | 22 Jul 2016 02:47 |
| Altmetrics: | http://www.altmetric.com/details.php?domain=psasir.upm.edu.my&doi=10.4314/tjpr.v14i11.8 |
| URI: | http://psasir.upm.edu.my/id/eprint/43642 |
| Statistic Details: | View Download Statistic |
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