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In vitro antiplasmodial properties of selected plants of Sabah


Citation

Shaari, Khozirah and Abdullah, Noor Rain and Mohd Janib, Siti Najila and Imiyabir, Zamrie and Madani, L. and Chomel, Rohaya and Mohamad, Rosilawati and Hashim, Nuziah and Goh, S. H. and Ismail, Zakiah (2011) In vitro antiplasmodial properties of selected plants of Sabah. Pertanika Journal of Science & Technology, 19 (1). pp. 11-17. ISSN 0128-7680; ESSN: 2231-8526

Abstract / Synopsis

The antiplasmodial activity of the crude extracts of thirty plant species collected from Sabah was evaluated using chloroquine-sensitive strain (D10) and chloroquine-resistant strain (Gombak A) of Plasmodium falciparum. Significant activities were observed for the bark extract of Polyalthia insignis (IC50 3.89 and 11.89 µg/ml against Gombak A and D10, respectively), the leaf extracts of Kopsia dasyrachis (4.62 µg/ml against Gombak A) and Litsea elliptibacea (IC50 8.88 µg/ml against Gombak A), as well as the leaf and bark extracts of Neouvaria acuminatissima (IC50 6.90-10.08 and 0.69 µg/ml against Gombak A and D10, respectively), and the bark extract of Polyalthia microtus (IC50 9.0 and 12.12 µg/ml against Gombak A and D10, respectively).


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Additional Metadata

Item Type: Article
Divisions: Institute of Bioscience
Publisher: Universiti Putra Malaysia Press
Keywords: Antimalarial; Kopsia dasyrachis; Lactate dehydrogenase assay; Neouvaria acuminatissima; Plasmodium falciparum; Polyalthia insignis
Depositing User: Noor Syafini Zamani
Date Deposited: 23 Nov 2015 11:18
Last Modified: 05 Jan 2016 16:28
URI: http://psasir.upm.edu.my/id/eprint/40635
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