Citation
Shaari, Khozirah and Abdullah, Noor Rain and Mohd Janib, Siti Najila and Imiyabir, Zamrie and Madani, L. and Chomel, Rohaya and Mohamad, Rosilawati and Hashim, Nuziah and Goh, S. H. and Ismail, Zakiah
(2011)
In vitro antiplasmodial properties of selected plants of Sabah.
Pertanika Journal of Science & Technology, 19 (1).
pp. 11-17.
ISSN 0128-7680; ESSN: 2231-8526
Abstract
The antiplasmodial activity of the crude extracts of thirty plant species collected from Sabah was evaluated using chloroquine-sensitive strain (D10) and chloroquine-resistant strain (Gombak A) of Plasmodium falciparum. Significant activities were observed for the bark extract of Polyalthia insignis (IC50 3.89 and 11.89 µg/ml against Gombak A and D10, respectively), the leaf extracts of Kopsia dasyrachis (4.62 µg/ml against Gombak A) and Litsea elliptibacea (IC50 8.88 µg/ml against Gombak A), as well as the leaf and bark extracts of Neouvaria acuminatissima (IC50 6.90-10.08 and 0.69 µg/ml against Gombak A and D10, respectively), and the bark extract of Polyalthia microtus (IC50 9.0 and 12.12 µg/ml against Gombak A and D10, respectively).
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Additional Metadata
| Item Type: |
Article
|
| Divisions: |
Institute of Bioscience |
| Publisher: |
Universiti Putra Malaysia Press |
| Keywords: |
Antimalarial; Kopsia dasyrachis; Lactate dehydrogenase assay; Neouvaria acuminatissima; Plasmodium falciparum; Polyalthia insignis |
| Depositing User: |
Noor Syafini Zamani
|
| Date Deposited: |
23 Nov 2015 03:18 |
| Last Modified: |
05 Jan 2016 08:28 |
| URI: |
http://psasir.upm.edu.my/id/eprint/40635 |
| Statistic Details: |
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