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Adenoviral based gene therapy for cancer in human and animals: a review


Citation

Tan, Seok Shin and Allaudin, Zeenathul Nazariah and Mohd Lila, Mohd Azmi (2011) Adenoviral based gene therapy for cancer in human and animals: a review. Pertanika Journal of Science & Technology, 19 (1). pp. 129-140. ISSN 0128-7680; ESSN: 2231-8526

Abstract / Synopsis

Adenovirus vector is the most common used vector in clinical gene therapy. The development of adenovirus from the first generation until the helper-dependent adenovirus vector has greatly reduced toxicity and immunogenicity. The helper-dependent adenovirus can also prolong transgene expression. Tissue- or disease-specific approach has been used to improve the specificity of adenoviral vector for cancer gene therapy. This review summarizes some adenoviral gene therapy and targeting approaches available for human cancer as well as animal cancer.


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Additional Metadata

Item Type: Article
Divisions: Faculty of Veterinary Medicine
Publisher: Universiti Putra Malaysia Press
Keywords: Adenovirus vector; Clinical; Gene therapy; Human cancer; Animal cancer
Depositing User: Noor Syafini Zamani
Date Deposited: 23 Nov 2015 09:44
Last Modified: 05 Jan 2016 16:58
URI: http://psasir.upm.edu.my/id/eprint/40590
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